Key result
Genetically reducing alpha 2 Na+ pumps by approximately 50% in mice augmented evoked Ca2+ transients despite normal cytosolic Na+ and resting Ca2+ concentrations.
Alpha 2/alpha 3 Na(+) pumps control local cytosolic Na(+) in PLasmERosomes, which in turn modulates local Ca(2+), endoplasmic reticulum Ca(2+) storage, and Ca(2+) signaling via the Na/Ca exchanger in neurons and astrocytes.
No takes yet. Share an insight, caveat, or question.
Highlights alpha-2 Na+ pump microdomain effects on Ca2+ signaling; leaves open translation to human cardiovascular disease.
Blaustein et al. (2002) studied this question. Genetically reduced alpha 2 Na(+) pumps vs. Normal alpha 2 Na(+) pumps was evaluated on Evoked Ca(2+) transients. Genetically reducing alpha 2 Na+ pumps by approximately 50% in mice augmented evoked Ca2+ transients despite normal cytosolic Na+ and resting Ca2+ concentrations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: