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March 5, 2020Science176 citations

A neurodevelopmental origin of behavioral individuality in the Drosophila visual system

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GLGerit Arne LinneweberMAMahéva AndriatsilavoSDSuchetana B. Dutta

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Abstract

, we demonstrate a link between stochastic variation in brain wiring and behavioral individuality. A visual system circuit called the dorsal cluster neurons (DCN) shows nonheritable, interindividual variation in right/left wiring asymmetry and controls object orientation in freely walking flies. We show that DCN wiring asymmetry instructs an individual's object responses: The greater the asymmetry, the better the individual orients toward a visual object. Silencing DCNs abolishes correlations between anatomy and behavior, whereas inducing DCN asymmetry suffices to improve object responses.

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Cite This Study

Linneweber et al. (2020) studied this question.

synapsesocial.com/papers/6a22a8e480ebe3feac149cd5https://doi.org/10.1126/science.aaw7182
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