Obesity in young men was associated with a significantly impaired brachial artery flow-mediated dilation in response to sustained handgrip exercise compared to lean controls (5.2% vs. 11.5%, p<0.001).
Cross-Sectional (n=28)
Single-blind
No
Does obesity impair brachial artery flow-mediated dilation in response to different shear stress profiles in young men?
Obesity in young men impairs endothelial function specifically in response to sustained shear stress (exercise), which may not be detected by standard brief reactive hyperemia tests.
Absolute Event Rate: 5.2% vs 11.5%
p-value: p=<0.001
Flow mediated dilation (FMD) stimulated by different shear stress stimulus profiles may recruit distinct transduction mechanisms, and provide distinct information regarding endothelial function. The purpose of this study was to determine whether obesity influences brachial artery FMD differently depending on the shear stress profile used for FMD assessment. The FMD response to a brief, intermediate, and sustained shear stress profile was assessed in obese (n = 9) and lean (n = 19) young men as follows: brief stimulus, standard reactive hyperemia (RH) following a 5 min forearm occlusion (5 min RH); intermediate stimulus, RH following a 15 min forearm occlusion (15 min RH); sustained stimulus, 10 min of handgrip exercise (HGEX). Brachial artery diameter and mean shear stress were assessed using echo and Doppler ultrasound, respectively, during each FMD test. There was no group difference in HGEX shear stress (p = 0.390); however, the obese group had a lower HGEX-FMD (5.2 ± 3.0% versus 11.5 ± 4.4%, p < 0.001). There was no group difference in 5 min RH-FMD (p = 0.466) or 15 min RH-FMD (p = 0.181); however, the shear stress stimulus was larger in the obese group. After normalization to the stimulus the 15 min RH-FMD (p = 0.002), but not the 5 min RH-FMD (p = 0.118) was lower in the obese group. These data suggest that obesity may have a more pronounced impact on the endothelium's ability to respond to prolonged increases in shear stress.
Slattery et al. (Sat,) conducted a cross-sectional in Obesity (n=28). Obesity vs. Lean controls was evaluated on Handgrip exercise-induced flow-mediated dilation (HGEX-FMD) (p=<0.001). Obesity in young men was associated with a significantly impaired brachial artery flow-mediated dilation in response to sustained handgrip exercise compared to lean controls (5.2% vs. 11.5%, p<0.001).
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