Key result
Simulated extracorporeal circulation of fresh heparinized human blood led to an increase in plasma levels of low-affinity platelet factor 4 within 2 minutes.
Why the study?
Does simulated extracorporeal circulation induce platelet release and thromboxane formation in fresh heparinized human blood?
Population
Fresh heparinized human blood
Design
Preclinical
Follow-up
2 hours
Authors
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Indicates potential early platelet activation risk in bypass circuits; leaves open targeted surface modifications.
Does simulated extracorporeal circulation induce platelet release and thromboxane formation in fresh heparinized human blood?
Simulated extracorporeal circulation rapidly induces platelet secretion, as evidenced by rising levels of low-affinity platelet factor 4 within 2 minutes.
Addonizio et al. (1979) studied Simulated extracorporeal circulation. Simulated extracorporeal circulation was evaluated on Platelet release (LA-PF4) and formation of thromboxane B2. Simulated extracorporeal circulation of fresh heparinized human blood led to an increase in plasma levels of low-affinity platelet factor 4 within 2 minutes.
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