Search for aglycone isoflavone from soybean as candidate for pelvic organ prolapse treatment: In silico study of TGF-β1, Hsp70, and Bcl-xl signals

Summary: The purpose of this study was to analyze molecular docking as a search for aglycone isoflavone in TGF-β, Hsp70, and apoptosis pathways that are useful for pelvic organ prolapse treatment. This in silico study involved procedures of searching for protein and nucleotide sequences, three-dimensional structure modeling, docking, and interaction analysis. Against TGF-β signal, the genistein facilitated interaction between TGF-β and TGF-β receptor, while against Hsp70 signal, the daidzein facilitated interaction of HSF and Hsp70. Against NF-κB signal for Bcl-xl gene, daidzein and glycitein facilitated interaction of NF-κB and Bcl-xl gene. It was concluded that aglycone isoflavone of the soybean could modulate TGF-β1, Hsp70, and Bcl-xl anti-apoptotic signals. Therefore, aglycone isoflavone derived from soybean can become an alternative nutrient or candidate for herbal product for pelvic organ prolapse treatment.