Key result
In a 61-year-old man with glucocorticoid-suppressible hyperaldosteronism, coexistent renal artery stenosis modified the renin, aldosterone, and blood pressure responses to dexamethasone.
Why the study?
Does coexistent renal artery stenosis alter the renin, aldosterone, and blood pressure response to dexamethasone in glucocorticoid-suppressible hyperaldosteronism?
Case Report (n=3)
Does coexistent renal artery stenosis alter the renin, aldosterone, and blood pressure response to dexamethasone in glucocorticoid-suppressible hyperaldosteronism?
Coexistent renal artery stenosis can alter the expected renin-aldosterone response to dexamethasone in patients with glucocorticoid-suppressible hyperaldosteronism, which normalizes after surgical correction.
Coexistent renal artery stenosis may confound dexamethasone testing in glucocorticoid-suppressible hyperaldosteronism; hypothesis-generating case observation needing prospective confirmation.
The responses of renin, aldosterone, and blood pressure to ACTH suppression with dexamethasone in a 61-yr-old man with glucocorticoid-suppressible hyperaldosteronism were modified by coexistent atheromatous renal artery stenosis (RAS). The apparent responsiveness of aldosterone to angiotensin-II resulting from RAS has implications for the regulation of steroidogenesis in this condition. After successful surgical correction of the RAS, the response changed and resembled that seen in two younger males (one his son) with uncomplicated glucocorticoid-suppressible hyperaldosteronism.
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Stowasser et al. (1993) conducted a case report in Glucocorticoid-suppressible hyperaldosteronism and coexistent renal artery stenosis (n=3). Dexamethasone was evaluated on Responses of renin, aldosterone, and blood pressure. In a 61-year-old man with glucocorticoid-suppressible hyperaldosteronism, coexistent renal artery stenosis modified the renin, aldosterone, and blood pressure responses to dexamethasone.