Key result
Current use of selective serotonin reuptake inhibitors did not decrease the risk of first-time acute myocardial infarction compared to nonusers of antidepressants (OR 0.9; 95% CI 0.5-1.8).
Why the study?
Does current use of SSRIs reduce the risk of first-time acute myocardial infarction in patients aged 75 years or younger free of predisposing conditions?
Population
16,458 patients aged 75 years or younger free of clinical conditions predisposing to ischaemic heart…
Comparison
Current use of selective serotonin reuptake… vs Nonuse of antidepressants
Design
Case-control
Authors
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No AMI risk reduction with SSRIs; leaves open effects in higher-risk groups or with longer-term use.
Case-Control (n=16,458)
Yes
Does current use of SSRIs reduce the risk of first-time acute myocardial infarction in patients aged 75 years or younger free of predisposing conditions?
Odds Ratio: 0.9 (95% CI 0.5–1.8)
Current use of SSRIs does not significantly decrease the risk of developing first-time acute myocardial infarction in patients without predisposing factors for ischemic heart disease.
Meier et al. (2001) conducted a case-control in Acute myocardial infarction (n=16,458). Selective serotonin reuptake inhibitors (SSRIs) vs. Nonusers of antidepressants was evaluated on First-time acute myocardial infarction (OR 0.9, 95% CI 0.5-1.8). Current use of selective serotonin reuptake inhibitors did not decrease the risk of first-time acute myocardial infarction compared to nonusers of antidepressants (OR 0.9; 95% CI 0.5-1.8).
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