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In the presence of enantiopure organocatalysts, 1‐cycloalkene‐1‐carboxaldehydes and various nitrones furnished fused isoxazolidines. Thus, some chiral pyrrolidinium salts catalyzed the formation of such cycloadducts in high diastereo‐ and enantioselectivity (up to 92% ee ). The predominant diastereomer, the exo one, was mostly obtained in excellent diastereoselectivity (> 99:1 dr ). Furthermore, after recrystallization of one of the cycloadducts, this was obtained enantiomerically pure (> 99% ee ). The absolute configuration of one of the cycloadducts was determined. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
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Karlsson et al. (2003) studied this question.
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