Key result
Catheter-based renal sympathetic denervation significantly reduced atrial fibrillation inducibility by 36.8% to 56.2% across different atrial sites compared to control (P < 0.05).
Why the study?
Does catheter-based renal sympathetic denervation reduce atrial fibrillation inducibility in a canine model of acute AF induced by hyper-sympathetic activity?
Does catheter-based renal sympathetic denervation reduce atrial fibrillation inducibility in a canine model of acute AF induced by hyper-sympathetic activity?
In a canine model, catheter-based renal sympathetic denervation significantly reduces atrial fibrillation inducibility and reverses atrial electrophysiological changes induced by hyper-sympathetic activity.
Does not support clinical use of renal denervation for AF; leaves open translation from canine models to human trials.
Background: Sympathetic activity involves the pathogenesis of atrial fibrillation (AF). Renal sympathetic denervation (RSD) decreases sympathetic renal afferent nerve activity, leading to decreased central sympathetic drive. The aim of this study was to identify the effects of RSD on AF inducibility induced by hyper-sympathetic activity in a canine model.
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Hou et al. (2013) studied Atrial fibrillation (n=16). Catheter-based renal sympathetic denervation vs. Sham ablation was evaluated on Atrial fibrillation induction rate (p=<0.05). Catheter-based renal sympathetic denervation significantly reduced atrial fibrillation inducibility by 36.8% to 56.2% across different atrial sites compared to control (P < 0.05).
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