Key result
Elevated NT-pro BNP levels were associated with prolonged hospital stay in multivariate analysis and correlated with mortality in patients with sepsis.
Why the study?
Elevated NT-proBNP is linked to cardiovascular dysfunction and systemic inflammation in sepsis, but it remained uncertain whether this reflects sepsis-related cardiac dysfunction that translates to poorer outcomes.
Does NT-proBNP level predict mortality and duration of hospital stay in patients with severe sepsis?
Observational (n=215)
Does NT-proBNP level predict mortality and duration of hospital stay in patients with severe sepsis?
Elevated NT-proBNP is associated with prolonged hospital stay and correlates with mortality in univariate analysis among patients with severe sepsis.
Elevated NT-proBNP may aid sepsis risk stratification; leaves open whether it improves outcomes or adds value beyond existing scores in prospective studies.
BACKGROUND: Sepsis is an important cause of mortality in intensive care units worldwide. The increased levels of N-terminal prohormone of brain natriuretic peptide (NT-pro BNP) are related with dysfunction of the cardiovascular system and systemic inflammation. It is uncertain whether this increase reflects sepsis-related cardiac dysfunction that translates to poorer outcomes. AIMS AND OBJECTIVES: The primary aim of this study was to evaluate the prognostic role of NT-pro BNP on the outcome and duration of hospital stay of patients admitted with sepsis. The secondary objective was to identify other associated risk factors for mortality in sepsis. PATIENTS AND METHODS: The patients who presented to emergency room with diagnosis of suspected sepsis were studied. Risk factors associated with outcome were studied by univariate analysis. The variables having statistical significance were further included in multivariate analysis to identify the independent predictors of mortality. RESULTS: A total of 215 patients with sepsis were included in this study. In univariate analyses, NT-pro BNP, procalcitonin, need of mechanical ventilation (MV), blood culture positivity, chronic kidney disease-chronic liver disease CKD-CLD, and diabetes mellitus were predictors of prolonged hospital stay, and it was same for multivariate analysis excluding procalcitonin. In univariate analysis, NT-pro BNP, MV, and DM were risk factors associated with mortality but in multivariate analysis showed significance only with MV and DM. CONCLUSION: There was a statistically significant correlation between NT-pro BNP levels and mortality. The other factors associated with increased mortality were diabetes mellitus and need of MV. In addition to the above factors, the presence of CKD and CLD was associated with increased duration of hospital stay. There was concordance between increased NT-pro BNP and elevated trop I, s creatinine, need of MV, and CKD.
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Reshmi et al. (2021) conducted an observational in Sepsis (n=215). N-terminal prohormone of brain natriuretic peptide (NT-pro BNP) was evaluated on Mortality and duration of hospital stay. Elevated NT-pro BNP levels were associated with prolonged hospital stay in multivariate analysis and correlated with mortality in patients with sepsis.
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