Key result
Children with cardiac disease had significantly higher median NT-proBNP levels (548 pg/mL) compared to those with infectious (193 pg/mL) or non-cardiac, non-infectious diseases (280 pg/mL).
Why the study?
NT-proBNP is a known marker of cardiac disease but may also be elevated in acute infections and non-cardiac diseases, prompting evaluation across conditions and clinical states.
Are NT-proBNP levels significantly different between children with cardiac disease and those with non-cardiac diseases, and do they correlate with clinical deterioration?
Observational (n=348)
Are NT-proBNP levels significantly different between children with cardiac disease and those with non-cardiac diseases, and do they correlate with clinical deterioration?
NT-proBNP is a useful marker of cardiac disease in children and correlates with clinical deterioration such as shock, rather than inflammatory status.
Answers are grounded in this paper and cite their sources.
May aid differentiation of cardiac from noncardiac illness in children; hypothesis-generating for deterioration prediction, warranting prospective validation.
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP), a well-known marker of cardiac disease, may be elevated in acute infections and other non-cardiac diseases. The aim of this study was to evaluate NT-proBNP levels in cardiac and non-cardiac diseases and found out the patient's clinical status that affects the NT-proBNP levels. METHODS: NT-proBNP levels were measured in three groups of children: a cardiac disease group, an infectious disease group, and a non-cardiac, non-infectious disease group. RESULT: In total, 348 children were enrolled, including 134 patients (38.5%) with cardiac disease, 170 patients (48.9%) with infectious disease, and 44 patients (12.6%) with non-cardiac, non-infectious disease. The NT-proBNP level of the cardiac disease group (median: 548 pg/mL; range: 5-35,000 pg/mL) was significantly higher than that of the infectious disease group (median: 193 pg/mL; range: 10-35,000 pg/mL) and the non-cardiac, non-infectious disease group (median: 280 pg/mL; range: 6-35,000 pg/mL). Regarding clinical status, the NT-proBNP levels were significantly higher in patients who needed mechanical ventilation support, oxygen therapy, or inotropic medication or had a change in mental status than in other patients. However, the systemic inflammatory response syndrome and mortality were not related to the NT-proBNP level. CONCLUSION: Among heterogeneous group of children, NT-proBNP level can be a useful marker of cardiac disease. Furthermore, the NT-proBNP levels were related to patients' clinical deteriorations, such as shock rather than the inflammatory status of patients.
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Kim et al. (2020) conducted an observational in Cardiac and non-cardiac diseases (n=348). Cardiac disease vs. Infectious and non-cardiac, non-infectious diseases was evaluated on NT-proBNP level. Children with cardiac disease had significantly higher median NT-proBNP levels (548 pg/mL) compared to those with infectious (193 pg/mL) or non-cardiac, non-infectious diseases (280 pg/mL).
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