Key result
Mimesys phosphorylcholine-coated oxygenators demonstrated no significant difference in hemodynamic resistance compared to uncoated oxygenators (p=0.97), but provided significantly better platelet protection when using crystalloid perfusates.
Why the study?
Does phosphorylcholine-coated oxygenators improve hemodynamic resistance and platelet protection compared to uncoated oxygenators in adults undergoing cardiopulmonary bypass?
RCT (n=196)
Open-label
Randomized
Yes
Does phosphorylcholine-coated oxygenators improve hemodynamic resistance and platelet protection compared to uncoated oxygenators in adults undergoing cardiopulmonary bypass?
Absolute Event Rate: 20.4% vs 21%
p-value: p=0.97
Phosphorylcholine-coated oxygenators provide superior platelet protection compared to uncoated oxygenators using crystalloid primes, without adversely affecting hemodynamic resistance during cardiopulmonary bypass.
No takes yet. Share an insight, caveat, or question.
Coated oxygenators improve platelet preservation with crystalloid perfusates without raising resistance; extends RCT evidence for selective use in CPB.
Myers et al. (2003) conducted an RCT in Cardiopulmonary Bypass (n=196). Mimesys Phosphorylcholine (PC)-Coated Oxygenators vs. Uncoated Monolyth oxygenators was evaluated on Hemodynamic resistance at 40 minutes on CPB (mmHg/LPM) (p=0.97). Mimesys phosphorylcholine-coated oxygenators demonstrated no significant difference in hemodynamic resistance compared to uncoated oxygenators (p=0.97), but provided significantly better platelet protection when using crystalloid perfusates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: