Why the study?
Does azelnidipine reduce aldosterone-induced oxidative stress and renal injury in uninephrectomized rats?
Population
Uninephrectomized rats subjected to 6 weeks treatment with aldosterone and 1% NaCl; and cultured rat…
Comparison
Azelnidipine 3 mg/kg per day orally vs Vehicle infusion, and hydralazine 5 mg/kg per…
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
May protect against aldosterone-induced renal injury beyond BP lowering; leaves open translation to human disease.
Does azelnidipine reduce aldosterone-induced oxidative stress and renal injury in uninephrectomized rats?
Azelnidipine protects against aldosterone-induced renal injury in rats through antioxidant mechanisms independent of blood pressure reduction.
Fan et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: