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The research investigates how shear-induced integrin signaling impacts platelet functions such as phosphatidylserine exposure and coagulation.

May 31, 2018BloodOpen Access

Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

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Randomized trial demonstrates inhibition of platelet thrombus formation in vivo, suggesting a role for integrin signaling in coagulation.

The research investigates how shear-induced integrin signaling impacts platelet functions such as phosphatidylserine exposure and coagulation.
Examined the role of Gα13-mediated outside-in signaling in platelet responses.
Utilized an inhibitor of integrin signaling to assess effects on thrombus formation and coagulation in vivo.
Inhibition of outside-in signaling reduces occlusive platelet thrombus formation.
The integrin inhibitor also significantly affects intravascular coagulation processes.

Pang et al. (2018) studied this question.

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