Key result
Idiopathic dilated cardiomyopathy was not associated with intrinsic alterations of Ca2+ uptake by sarcoplasmic reticulum compared to nonfailing hearts (Vmax 593 vs 593 nmol/mg-min).
Observational (n=15)
Absolute Event Rate: 593% vs 593%
Abnormal Ca2+ handling in human idiopathic dilated cardiomyopathy does not appear to result from intrinsic alterations in sarcoplasmic reticulum Ca2+ uptake.
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Does not support intrinsic SR Ca2+ uptake defects in IDC; leaves open other Ca2+ handling mechanisms.
Movsesian et al. (1989) conducted an observational in Idiopathic dilated cardiomyopathy (n=15). Idiopathic dilated cardiomyopathy vs. Nonfailing human hearts was evaluated on Ca2+ uptake by sarcoplasmic reticulum (Vmax in nmol/mg-min). Idiopathic dilated cardiomyopathy was not associated with intrinsic alterations of Ca2+ uptake by sarcoplasmic reticulum compared to nonfailing hearts (Vmax 593 vs 593 nmol/mg-min).
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