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March 6, 2009American Journal of Respiratory and Critical Care MedicineOpen Access

Assessing the Reproducibility of Asthma Candidate Gene Associations, Using Genome-wide Data

Angela J. Rogers Benjamin A. Raby Jessica Lasky‐Su Amy Murphy Ross Lazarus Barbara J. Klanderman Jody Sylvia John Ziniti Christoph Lange Juan C. Celedón Edwin K. Silverman Scott T. Weiss

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Key Points

This research aims to assess previously reported gene associations related to asthma and evaluate additional genetic variations contributing to asthma susceptibility.
Genotyping was performed using Illumina Human Hap 550Kv3 BeadChip SNP arrays in 422 nuclear families.
Candidate genes were selected based on reports of prior gene associations with asthma from two or more populations.
Family-based association testing was used to analyze the association data for identified genes.
Ten SNPs in six candidate genes were significantly associated with asthma, including integrin beta(3) [ITGB3].
Fifteen additional genes showed some association with asthma but were not statistically significant after multiple comparisons adjustment.

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Implication

Evaluates gene associations with asthma, indicating potential gene contributions to susceptibility.

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Cite This Study

Rogers et al. (2009) studied this question.

synapsesocial.com/papers/6a22e69840a1f8b699605ae1 https://doi.org/10.1164/rccm.200812-1860oc

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