A Controlled Study of Three Methods of Prophylaxis against Streptococcal Infection in a Population of Rheumatic Children

ORAL and injectable agents are now being widely used to prevent streptococcal infections in patients who have had rheumatic fever.1 , 2 The choice of treatment has generally been made arbitrarily because the comparative effectiveness of the available agents has not been adequately determined in clinical trials. For statistically valid results, any trial studies would need to ensure that the prophylactic agents were given to groups of patients whose numbers were large enough to be adequately comparable in certain crucial aspects of their rheumatic background.A previous report presented the results of the first two years of observation on 405 patients in . . .