Complete left bundle-branch block in a necropsy population was associated with extreme anatomical left ventricular hypertrophy and significantly higher total heart weight compared to controls.
Observational (n=2,500)
Electrocardiograms of 2500 consecutive patients who died in hospital were reviewed in order to study the relation ofcomplete left bundle-branch block to pathological determinants ofanatomical left ventricular hypertrophy. Of these, 43 patients demonstrated complete left bundle-branch block and all but two had anatomical left ventricular hypertrophy at necropsy. -Mean values of total heart weight and percentage total heart weight of normal were significantly higher in this group of 43 patients with complete left bundle-branch block than in a control necropsy group of 300 patients with anatomical left ventricular hypertrophy but without complete left bundle-branch block. Left ventricular wall thickness did not correlate with other measures of left ventricular muscle mass. Commonly used electrocardiographic voltage criteria for left ventricular hypertrophy identified approximately one-half of the 41 patients with left bundle-branch block and anatomical left ventricular hypertrophy. The degree of electrocardiographic voltage abnormality correlated modestly with total heart weight and percentage total heart weight of normal. A group of 25 patients was studied in whom electrocardiograms were available before and after complete left bundle-branch block. Normal voltage before left bundlebranch block tended to remain normal, while abnormally high voltage tended to fall after complete left bundle-branch block developed. Complete left bundle-branch block in a necropsy population characterised a group with extreme anatomical left ventricular hypertrophy. The sensitivity of the usual electrocardiographic left ventricular hypertrophy voltage criteria in the presence of complete left bundle- branch block is only slightly less than in patients with left ventricular hypertrophy alone. The degree of electrocardiographic voltage abnormality with complete left bundle-branch block shows modest correlation with degree of anatomical left ventricular hypertrophy.
Zmyslinski et al. (Fri,) conducted a observational in Complete left bundle-branch block and left ventricular hypertrophy (n=2,500). Complete left bundle-branch block vs. Left ventricular hypertrophy without complete left bundle-branch block was evaluated on Total heart weight and percentage total heart weight of normal. Complete left bundle-branch block in a necropsy population was associated with extreme anatomical left ventricular hypertrophy and significantly higher total heart weight compared to controls.
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