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. We then confirmed this inverse relationship by measurements of platelets during two additional, physiologically highly relevant situations: The dynamic spreading of platelets on a surface and platelets subjected to a spatial confinement, where a decrease in volume was also accompanied by an increase in stiffness and platelets subjected to spatial confinement showed a significantly larger volume compared to unconfined platelets, with a correspondingly lower stiffness, respectively. In conclusion, our SICM analysis revealed a universal, inverse correlation between platelet stiffness and volume change, opening up new perspectives in platelet research.
Krutzke et al. (Fri,) studied this question.
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