Hemodynamic Alterations in Acute Myocardial Infarction. I. Cardiac Output, Mean Arterial Pressure, Total Peripheral Resistance, “Central” and Total Blood Volumes, Venous Pressure and Average Circulation Time 12

Edward D. Freis; Harold W. Schnaper; Robert L. Johnson; George E. Schreiner

doi:10.1172/jci102584

February 1, 1952Journal of Clinical InvestigationOpen Access

Hemodynamic Alterations in Acute Myocardial Infarction. I. Cardiac Output, Mean Arterial Pressure, Total Peripheral Resistance, “Central” and Total Blood Volumes, Venous Pressure and Average Circulation Time 12

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Why the study?

What are the hemodynamic alterations in acute myocardial infarction compared to normal subjects and hypertensive patients?

Key Points

This research aims to explore the hemodynamic changes that occur during acute myocardial infarction.
Conducted hemodynamic studies using the Hamilton dye injection method and other techniques.
Analyzed data from 11 patients with acute myocardial infarction and compared them to normal and hypertensive subjects.
Utilized bedside measurement techniques to assess cardiac output and additional hemodynamic parameters.
Significant alterations in cardiac output and venous pressure were observed in myocardial infarction patients compared to controls.
Total blood volume and mean arterial pressure differed notably across patient groups.
Findings suggest the Hamilton dye method can provide reliable bedside assessments for acutely ill patients.

Structured PICO

What are the hemodynamic alterations in acute myocardial infarction compared to normal subjects and hypertensive patients?

P

Population

23 subjects total: 11 patients with acute myocardial infarction (divided clinically into mild, moderately severe/severe, and cardiogenic shock), 7 normal healthy young male medical students, and 5 hypertensive patients.

I

Intervention

Hemodynamic measurements including cardiac output via the Hamilton dye injection method (T-1824), arterial pressure via strain gauge, and central venous pressure via catheterization.

C

Comparator

Normal subjects and hypertensive patients.

O

Outcome

Hemodynamic parameters including cardiac output, mean arterial pressure, total peripheral resistance, central and total blood volumes, venous pressure, and average circulation time.surrogate

Cardiogenic shock in acute myocardial infarction is characterized by a marked reduction in stroke volume and a compensatory increase in total peripheral resistance, rather than hypovolemia.

Limitations

Small series of patients
Method for central blood volume was not precise due to variable contribution of blood from other large veins entering the right heart

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Implication

Challenges hypovolemia-centric views of cardiogenic shock; leaves open validation with modern hemodynamics in larger cohorts.

Abstract

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Discussion

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Cite This Study

Freis et al. (1952) studied this question.

synapsesocial.com/papers/6a22fc45e319d28108d26c32 https://doi.org/10.1172/jci102584

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Hemodynamic Alterations in Acute Myocardial Infarction. I. Cardiac Output, Mean Arterial Pressure, Total Peripheral Resistance, “Central” and Total Blood Volumes, Venous Pressure and Average Circulation Time 12

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Hemodynamic Alterations in Acute Myocardial Infarction. I. Cardiac Output, Mean Arterial Pressure, Total Peripheral Resistance, “Central” and Total Blood Volumes, Venous Pressure and Average Circulation Time 12

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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