October 1, 1950Open Access

Blood Volume Studies in Shock Resulting From Myocardial Infarction. I. Studies With Evans Blue Dye (T-1824) 1

CAClarence M. AgressCentury Health MRMarvin J. RosenburgUnited States Department of Veterans Affairs ASAbraham SchneidermanUnited States Department of Veterans Affairs

Structured PICO

Does shock resulting from acute myocardial infarction cause a reduction in circulating blood volume?

Population

32 patients with acute myocardial infarction, divided into non-shock (n=10), moderate shock (n=10), and severe shock (n=12).

Intervention

Blood volume measurement using Evans blue dye (T-1824).

Comparator

Non-shock patients and convalescent/expected normal blood volumes.

Outcome

Whole blood volume and plasma volume (cc per kg) and percent deviation from normal.surrogate

Cardiogenic shock following acute myocardial infarction is associated with a significant reduction in circulating blood volume, distinguishing it from pure congestive heart failure.

Abstract

The ominous form of circulatory failure which may accompany severe myocardial infarction car- ries a distressing mortality of some 79%o (1).

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