Prenatal sonographic vascular parameters, including diameters of the DA, aortic isthmus, arch, AAO, and MPA, and LCCA-LSA distance, are independent predictors of CoA presence (overall model AUC 0.997).
Case-Control (n=381)
Do prenatal sonographic vascular parameters differ between fetuses with and without coarctation of the aorta, and can they predict CoA presence?
Prenatal sonographic vascular parameters, including LCCA-LSA distance and diameters of the DA, aortic isthmus, arch, AAO, and MPA, are independent predictors of coarctation of the aorta with high diagnostic accuracy.
Effect estimate: AUC 0.997
p-value: p=< 0.05
ABSTRACT Purpose To investigate changes in ultrasound vascular parameters in fetuses with coarctation of the aorta (CoA) and risk factors for CoA presence. Materials and Methods Fetuses of CoA and healthy controls without CoA confirmed after birth were prospectively enrolled. All ultrasound‐related vascular parameters were analyzed. Results Forty‐five CoA positive fetuses and 336 age‐matched ( p > 0.05) healthy fetuses were enrolled. Compared with the normal fetuses, CoA positive fetuses exhibited significantly ( p < 0.05) different ultrasound parameters. Significant ( p < 0.05) independent risk factors of CoA presence were DA diameter, isthmus diameter at 3 vessel trachea view, arch diameter, left common carotid artery (LCCA) to left subclavian artery (LSA) distance, ascending aorta (AAO) diameter, and main pulmonary artery (MPA) diameter. The area under the receiver operating characteristics curve (AUC) and cutoff value were 0.997 and 0.395, respectively, for the overall fitted model with the mean gestational age 28 weeks, 0.704 and 0.33 cm for DA diameter, 0.891 and 0.27 cm for isthmus diameter, 0.808 and 0.26 cm for aortic arch diameter, 0.676 and 0.28 mm for LCCA‐LSA distance, 0.707 and 0.39 cm for AAO diameter, and 0.566 and 0.86 cm for MPA diameter, with a high negative predictive value all above 0.90. Conclusion CoA positive fetuses exhibit significant differences in prenatal sonographic vascular parameters, and the LCCA‐LSA distance and diameter of DA, aortic isthmus, arch, AAO, and MPA are independent risk factors for CoA presence.
Chen et al. (Sun,) conducted a case-control in Coarctation of the aorta (n=381). Prenatal sonographic vascular parameters vs. Healthy fetuses without CoA was evaluated on Presence of coarctation of the aorta (AUC 0.997, p=< 0.05). Prenatal sonographic vascular parameters, including diameters of the DA, aortic isthmus, arch, AAO, and MPA, and LCCA-LSA distance, are independent predictors of CoA presence (overall model AUC 0.997).