Key result
Nuclear magnetic resonance spectroscopy revealed that the regulatory domain of cardiac troponin C exists in a closed conformation even in the Ca2+-bound state, differing from skeletal troponin C.
The unexpected closed conformation of Ca2+-bound cardiac troponin C provides a structural basis for understanding cardiac muscle regulation and the mechanism of calcium-sensitizing drugs.
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Challenges predicted troponin models; leaves open implications for calcium-sensitizer mechanisms in humans.
Sia et al. (1997) studied Cardiac muscle contraction. Nuclear magnetic resonance spectroscopy revealed that the regulatory domain of cardiac troponin C exists in a closed conformation even in the Ca2+-bound state, differing from skeletal troponin C.
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