Key result
Monensin enhanced 3H-ouabain binding by approximately 40% and shifted toxicity threshold, while lidocaine lowered binding by about one third and extended the tolerated concentration range.
Why the study?
Do monensin and lidocaine modulate ouabain binding and toxicity in guinea-pig ventricular myocardium?
Population
Beating ventricular strips from guinea-pig heart and isolated cardiac membranes
Comparison
Monensin (3 x 10(-6)M) or Lidocaine (2 x 10(-4)M) vs Control (baseline ouabain binding)
Design
Preclinical
Authors
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Should not guide digitalis use in patients; leaves open Na+-dependent binding modulation in intact myocardium.
Do monensin and lidocaine modulate ouabain binding and toxicity in guinea-pig ventricular myocardium?
The study provides evidence that ouabain binding and toxicity are indirectly modulated by drugs that alter the cellular Na+ load.
Borst et al. (1991) studied this question. Monensin and Lidocaine was evaluated on Concentration-dependence of ouabain binding and ouabain effects. Monensin enhanced 3H-ouabain binding by approximately 40% and shifted toxicity threshold, while lidocaine lowered binding by about one third and extended the tolerated concentration range.
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