Why the study?
Do thiamylal and halothane reduce the slow inward current in isolated rat ventricular cells?
Population
Single isolated rat ventricular cells obtained by an enzymatic dissociation method
Comparison
Thiamylal (10(-4) mol . l-1) and halothane (1%) vs Control value (baseline/untreated)
Design
Preclinical
Authors
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May underlie negative inotropy in rat myocytes; leaves open translation to human anesthesia.
Do thiamylal and halothane reduce the slow inward current in isolated rat ventricular cells?
Thiamylal and halothane directly reduce the slow inward calcium current in isolated rat ventricular cells, providing a mechanism for their negative inotropic effects.
Ikemoto et al. (1985) studied this question.
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