In vivo correlation between semi‐quantitative hemodynamic parameters and Ktrans derived from DCE‐MRI of brain tumors

Dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow‐up. Without complicated calculation, a semiquantitative parameter – modified initial area under the curve (mIAUC c ) – was proposed for better correlation with volume transfer constant ( K trans ) by computer simulation. In this study, we aim to further investigate the correlation between mIAUC c and K trans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3‐Tesla clinical MR scanner. The results showed that mIAUC c was highly correlated with K trans with the correlation coefficient of 0.913. Although the ideals of K trans and mIAUC c are different, mIAUC c does the trick for brain tumors evaluations in DCE‐MRI. It reveals that mIAUC c could be an alternative for physiological condition evaluation in DCE‐MRI.