Key result
Persistent viral infection induces changes in cellular differentiation, the chromosome apparatus, and apoptosis of peripheral blood lymphocytes.
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Review
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This review discusses the cellular and molecular mechanisms underlying long-term viral persistence, including effects on cellular differentiation and apoptosis.
In the article a view of investigators on the modern understanding of long-term viral persistence forming mechanisms on cellular and molecular levels has been presented. A question on the role of persistent virus in the induction of changes in cellular differentiation character, of chromosome apparatus and of apoptosis of peripheral blood lymphocytes has been discussed.
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Жукова et al. (2003) studied this question. Persistent viral infection induces changes in cellular differentiation, the chromosome apparatus, and apoptosis of peripheral blood lymphocytes.
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