Key result
Cardiac receptor stimulation evoked reduced reflex changes in renal vascular resistance and mean arterial pressure in late-pregnant compared with virgin rats (P<0.05).
Why the study?
Does cardiac receptor stimulation affect renal vascular resistance differently in pregnant versus virgin rats?
Does cardiac receptor stimulation affect renal vascular resistance differently in pregnant versus virgin rats?
Reflex changes in renal vascular resistance during cardiac receptor stimulation are reduced in pregnant compared to virgin rats, a difference that does not appear to involve differential effects of ANG II.
Blunted reflex renal vasoconstriction during cardiac stimulation in pregnant rats; leaves open relevance to human gestational hemodynamics.
Stimulation of cardiac receptors (CR) evokes blunted reflex reductions in mean arterial pressure (MAP) in pregnant compared with virgin rats. Because CR-mediated sympathoinhibition has preferential effects on the kidney, we tested whether, during pregnancy, renal vascular resistance (RVR) changes less in response to CR stimulation and investigated possible mechanisms. MAP, right atrial pressure, renal sympathetic nerve activity (RSNA), renal blood flow (RBF), and RVR were measured in anesthetized animals in response to CR stimulation by graded atrial injections of saline. Baseline MAP and RVR and reflex changes in these variables during CR stimulation were reduced in late-pregnant vs. virgin rats (P<0.05). Reflex changes in RSNA were attenuated in pregnant rats, but changes in RBF as a function of RSNA were similar in both groups. ANG II AT(1)-receptor blockade increased basal RBF more in virgin rats (P<0.05), but between-group differences in reflex changes in MAP, RSNA, and RVR were maintained after AT(1) blockade. Thus during CR simulation, reflex changes in RVR were reduced in pregnant versus virgin rats. This difference does not appear to involve differential effects of ANG II.
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Hines et al. (2000) studied Pregnancy. Cardiac receptor stimulation vs. Virgin rats was evaluated on Reflex changes in renal vascular resistance (RVR) and mean arterial pressure (MAP) (p=<0.05). Cardiac receptor stimulation evoked reduced reflex changes in renal vascular resistance and mean arterial pressure in late-pregnant compared with virgin rats (P<0.05).
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