Specialized Solid Form Screening Techniques

Solid form screening is an integral part of many development plans at various companies and includes polymorph, salt, cocrystal, amorphous, and amorphous dispersion screens. There are a number of traditional solvent- and nonsolvent-based methods that are employed for these screens. Over time, specialized screens have been developed to deal with difficult molecules and situations or to push the limits of traditional experiments. This contribution outlines a variety of specialized screening approaches for polymorphs, salts, cocrystals, and amorphous dispersions. Many techniques are amenable to laboratory equipment and can be incorporated with minimal start-up time, while others are very specific and will need specialized equipment and/or expertise.