A genetic risk score based on 5 AF-susceptible SNPs was significantly associated with atrial fibrillation recurrence after catheter ablation, increasing the risk of recurrence by 13% per risk allele (HR 1.13).
Cohort (n=746)
Yes
Does a genetic risk score using 5 AF-susceptible SNPs predict the recurrence of atrial tachyarrhythmia in patients undergoing catheter ablation for atrial fibrillation?
A novel genetic risk score using 5 AF-susceptible SNPs independently predicts the recurrence of atrial tachyarrhythmia after catheter ablation in a Korean population.
Hazard Ratio: 1.13 (95% CI 1.03–1.24)
p-value: p=0.007
BACKGROUND AND OBJECTIVES: The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF. METHODS: We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation. RESULTS: ]), which showed modest associations with AF recurrence. The GRS was significantly associated with AF recurrence (hazard ratio HR per each score, 1.13; 95% confidence interval CI, 1.03-1.24). Patients with intermediate (GRS 4-6) and high risks (GRS 7-10) showed HRs of 2.00 (95% CI, 0.99-4.04) and 2.66 (95% CI, 1.32-5.37), respectively, compared to patients with low risk (GRS 0-3). CONCLUSIONS: Our novel GRS using 5 AF-susceptible SNPs was strongly associated with AF recurrence after catheter ablation in Korean population, beyond clinical risk factors. Further efforts are warranted to construct a generalizable, robust genetic prediction model which can guide the optimal treatment strategies.
Choe et al. (Tue,) conducted a cohort in Atrial fibrillation (n=746). Genetic risk score (GRS) based on 5 AF-susceptible SNPs vs. Lower genetic risk score (per 1-point decrease) was evaluated on Recurrence of atrial tachyarrhythmia after a 3-month blanking period (HR 1.13, 95% CI 1.03-1.24, p=0.007). A genetic risk score based on 5 AF-susceptible SNPs was significantly associated with atrial fibrillation recurrence after catheter ablation, increasing the risk of recurrence by 13% per risk allele (HR 1.13).