Key result
Synaptopodin-deficient mice display impaired recovery from podocyte foot process effacement and nephrotic syndrome, with Synpo-T serving as a backup for Synpo-long in podocytes.
Synaptopodin regulates the actin-bundling activity of α-actinin in highly dynamic cell compartments, with Synpo-T serving as a functional backup in synpo-/- podocytes.
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Hypothesis-generating for isoform-specific podocyte repair; leaves open translation to human glomerular disease.
Asanuma et al. (2005) studied Protamine sulfate-induced podocyte foot process effacement and LPS-induced nephrotic syndrome. Synaptopodin deficiency (synpo-/-) vs. Wild-type was evaluated on Recovery from protamine sulfate-induced podocyte foot process effacement and LPS-induced nephrotic syndrome. Synaptopodin-deficient mice display impaired recovery from podocyte foot process effacement and nephrotic syndrome, with Synpo-T serving as a backup for Synpo-long in podocytes.
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