Application of biopolymers in hydrogels for tissue repair with bioextracts: systematic review

Biomaterials engineering has evolved rapidly, with a particular emphasis on biofunctionalized hydrogels for tissue repair. This systematic review, based on PRISMA 2020 guidelines, analyzed 75 studies from the SCOPUS database, evaluating biopolymers combined with bioextracts for wound healing. Bibliometric analysis revealed a significant increase in publications from 2022 onward, with a focus on Biomaterials Engineering and Biotechnology. The most productive centers were the departments of Medical Nanotechnology, Biotechnology, and Biomedical Engineering. Among the central authors, Li, Doostan, and Karamanlioglu stood out. The most cited articles focused on antimicrobial and regenerative strategies. China leads in scientific production, followed by India and the USA. The most frequent keywords included “wound healing,” “hydrogel,” and “biocompatibility.” In vitro studies (53%) and combined in vitro/in vivo studies (43%) predominated. It is concluded that biofunctionalized hydrogels hold high therapeutic potential but require methodological standardization and clinical validation for safe application in regenerative medicine.