February 12, 2002Circulation
Principal Component Analysis of the T Wave and Prediction of Cardiovascular Mortality in American Indians
Key result
An increased PCA ratio of the T-wave loop (>90th percentile) was associated with a 3.68-fold increased risk of cardiovascular mortality in women and a 2.77-fold increased risk in men.
Why the study?
Does principal component analysis of the T-wave vector loop predict cardiovascular mortality better than QT interval dispersion in American Indians?
Population
1839 American Indian participants in the first Strong Heart Study examination
Comparison
Principal component analysis of the T-wave… vs QT interval dispersion (QTd)
Design
Cohort
Follow-up
mean 3.7+/-0.9 years
Authors
Discussion
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Member takes
Implication
T-wave PCA ratio signals CV mortality risk across sexes; leaves open incremental value over QT dispersion before clinical adoption.
Study Design
Type
Cohort (n=1,839)
Structured PICO
Does principal component analysis of the T-wave vector loop predict cardiovascular mortality better than QT interval dispersion in American Indians?
P
Population
1,839 American Indian participants in the first Strong Heart Study examination followed for a mean of 3.7 years to assess predictors of cardiovascular mortality.
E
Exposure
Principal component analysis (PCA) of the T-wave vector loop (PCA ratio)
C
Comparator
QT interval dispersion (QTd)
O
Outcome
Cardiovascular (CV) mortalityhard clinical
Main Result
Hazard Ratio: 3.68 (95% CI 1.54–8.83)
p-value: p=0.043
Abnormalities of repolarization measured by PCA of the T-wave loop predict cardiovascular death in both men and women, outperforming QT dispersion which only predicted risk in women.
Cite This Study
Okin et al. (2002) conducted a cohort in Cardiovascular mortality risk (n=1,839). Increased PCA ratio (>90th percentile) vs. PCA ratio ≤90th percentile was evaluated on Cardiovascular mortality (HR 3.68, 95% CI 1.54-8.83, p=0.043). An increased PCA ratio of the T-wave loop (>90th percentile) was associated with a 3.68-fold increased risk of cardiovascular mortality in women and a 2.77-fold increased risk in men.