Why the study?
The study was designed to investigate the effect of early and late administration of phenylephrine during ischemia against regional ischemia-reperfusion injuries in an isolated rat heart model.
Does phenylephrine administration during ischemia reduce ischemia-reperfusion injury in an isolated rat heart model?
Population
Isolated rat hearts
Comparison
Early vs late phenylephrine with or without 5HD vs ischemia-reperfusion control
Design
Randomized preclinical isolated heart study
Follow-up
60 min of reperfusion
Authors
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Phenylephrine may induce mKATP-mediated late perconditioning in rat hearts; hypothesis-generating and leaves open clinical translation.
Does phenylephrine administration during ischemia reduce ischemia-reperfusion injury in an isolated rat heart model?
Phenylephrine induces late perconditioning against ischemia-reperfusion injury via mitochondrial potassium channels in an isolated rat heart model.
Nazari et al. (2019) studied this question.
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