The histological changes occurring in the pubic joint of hormonally treated intact or hypophysectomized mice have been studied. Estrogen treatment resulted in bone resorption and transformation of the cartilage caps of the pubic bones to fibrocartilage in intact mice but not in hypophysectomized mice. Furthermore, relaxin failed to influence the appearance of the pubic joint of estrogen-primed hypophysectomized mice, whereas it induced the development of long interpubic ligaments in intact mice. When growth hormone (STH) was administered to hypophysectomized mice, the pubic joints responded to estrogen with bone resorption and transformation of the cartilage caps to fibrocartilage. STH treatment also restored the ability of the pubic joint of hypophysectomized mice to proliferate long interpubic ligaments when estrogen and relaxin were administered. Progesterone specifically inhibited ligament formation due to relaxin injection without altering the histological changes associated with estrogen treatment, both in intact mice and in STH-maintained, hypophysectomized mice. (Endocrinology76: 876, 1965)
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Steinetz et al. (1965) studied this question.