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Cyproterone acetate was used in combination with either 35 or 50 μg ethinyl oestradiol in a double-blind comparison of their effects on acne in females. There were no significant differences between the two groups in the degree of improvement in acne as assessed objectively by the investigators, or subjectively by the patients using a visual analogue scale. Oestrogen related side-effects were significantly lower in the 35 μg group during the course of the 9-month stud.
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Colver et al. (1988) studied this question.
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