IN 1927 SMITH (I) showed that the presence of the pituitary was necessary for the proper functioning of the thyroid gland in the rat. Since that time numerous workers have shown that suitable extracts of the anterior pituitary can produce hyperplasia of the thyroids in various laboratory animals: the guinea pig (2, 3), the dog (4, 5), the pigeon (6), the hen (7) the chick (8), the duck (9), the rat (10). To date the only definite source of thyrotropic hormone has been the hypophysis, and the isolation of a thyrotropic substance from urine, plasma, or other tissues awaits proof. There have been numerous reports of the finding of thyrotropic substance in the urine of myxedematous patients (11, 12, 13, 14), and in hyperthyroid patients (15); in menopausal patients (16); and in normal urine and serum (11, 13) but other workers have been unable to confirm these findings (17,18,19, 20).
No takes yet. Share an insight, caveat, or question.
Maxwell Shaw Jones (1939) studied this question.