Key result
Hemodialysis patients had significantly longer interatrial and intraatrial electromechanical delay intervals compared to healthy controls (all p<0.01), which were reduced after a single HD session.
Why the study?
Does a single hemodialysis session alter atrial electromechanical delay times and mechanical functions in non-diabetic, normotensive hemodialysis patients?
Observational (n=70)
Does a single hemodialysis session alter atrial electromechanical delay times and mechanical functions in non-diabetic, normotensive hemodialysis patients?
p-value: p=<0.01
A single hemodialysis session acutely reduces prolonged atrial electromechanical delay intervals and mechanical volumes, highlighting the impact of volume-preload changes on electrical and structural remodeling.
Acute hemodialysis-associated reductions in atrial electromechanical delay should not yet change practice; hypothesis-generating for volume effects on conduction.
BACKGROUND/AIMS: Abnormalities in atrial electromechanical delay (EMD) times and mechanical functions are considered as independent predictors of atrial fibrillation. However, to date, effects of a single hemodialysis (HD) session and acute volume-preload changes on atrial-EMD functions have not been investigated by Tissue Doppler Echocardiography (TDE). The aim of the present study was to evaluate atrial-EMD times and mechanical functions in HD patients. METHODS: Thirty-five non-diabetic, normotensive HD patients and 35 healthy control subjects were enrolled in the study. Standard and TDE performed before mid-week dialysis session for hemodialysis group and on admission for control group. RESULTS: Interatrial and left-right intraatrial-EMD intervals and left atrial mechanical volumes were significantly longer in hemodialysis group compared to controls (all p<0.01) and were reduced after HD session. Furthermore, removed ultrafiltration volume was associated with reduction in atrial-EMD intervals and functional volumes. LA-passive emptying volume, ultrafiltration volume, LV-E/E' ratio, and Vp were independent predictors of interatrial-EMD. CONCLUSIONS: The present study confirms negative effects in HD patients of structural remodeling and reveals negative effects of electrical remodeling. Prolonged inter and intraatrial-EMD intervals should be the underlying pathophysiological factors of increased rate of atrial fibrillation in the HD population.
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Tekçe et al. (2013) conducted an observational in Hemodialysis (n=70). Hemodialysis vs. Healthy controls was evaluated on Interatrial and left-right intraatrial-EMD intervals and left atrial mechanical volumes (p=<0.01). Hemodialysis patients had significantly longer interatrial and intraatrial electromechanical delay intervals compared to healthy controls (all p<0.01), which were reduced after a single HD session.
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