The histone f2a was found to stimulate markedly oxygen consumption of isolated heart and liver mitochondria, in the absence of a phosphate acceptor system, but in the presence of inorganic phosphate. Octylguanidine, but not oligomycin or aurovertin, markedly inhibited the histone-induced increment in respiration. On the other hand the histone stimulated oligomycin- or aurovertin-inhibited respiration, but had no effect on respiration inhibited by octylguanidine. The stimulation of oxygen consumption by f2a was accompanied by an energy-dependent K+ efflux.
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Johnson et al. (1966) studied this question.
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