CHADS2 and CHA2DS2-VASc scores in evaluating the prognosis of maintenance hemodialysis patients

Background: The risk of mortality and cardiovascular disease is above the average in maintenance hemodialysis (MHD) patients. Nevertheless, there is still no way to assess this risk . Hypothesis: There may be important value in evaluating the prognosis of MHD by using CHADS2 and CHA2DS2-VASc scores. Methods: 112 patients who were treated with MHD were enrolled. On the basis of the scores, the investigators divided the patients into 3 groups separately. Kaplan-Meier survival analysis was used as a comparision the of the incidence between all-cause mortality and cardiovascular events. Multivariate COX regression analysis was used to illustrate the influencing elements of all-cause mortality and cardiovascular events. Area under Receiver Operating Characteristic Curve (AUC) was applied to estimate that if CHADS2 and CHA2DS2-VASc scores could predict all-cause mortality and cardiovascular events. Results: CHADS2 score showed statistical significance in the incidence of all-cause mortality in the 3 groups (P＜0.01). CHA2DS2-VASc score showed statistical significance both in the incidence of cardiovascular events and all-cause mortality in the 3 groups (P＜0.05). CHA2DS2-VASc score and troponin I (cTnI) are both risk factors for MHD patients to predict all-cause mortality.What’s more, CHA2DS2-VASc score is an independent risk factor for cardiovascular events,which were showed by Multivariate COX regression analysis. For all-cause mortality,the scores have great predictive value . Conclusions: Both CHADS2 scores and CHA2DS2-VASc scores can predict the incidence of all-cause mortality in MHD patients.As for all-cause mortality, CHA2DS2-VASc score and cTnI are dangers. CHA2DS2-VASc score is an independent danger and can predict the occurrence of cardiovascular events.