Key result
After induced myocardial infarction in transgenic mice, MMP-2 and MMP-9 promoter induction peaked at 7 days (64 +/- 6% and 53 +/- 6% of LV epicardial area, respectively; P<0.05).
Why the study?
Does myocardial infarction induce distinct spatiotemporal patterns of MMP-2 and MMP-9 promoter activation in transgenic mice?
Population
Transgenic mice in which the MMP-2 or MMP-9 promoter sequence was fused to the beta-galactosidase reporter
Design
Preclinical
Follow-up
up to 28 days
Authors
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No immediate clinical implications for MMP targeting post-MI; leaves open translation of murine promoter patterns to human remodeling.
Does myocardial infarction induce distinct spatiotemporal patterns of MMP-2 and MMP-9 promoter activation in transgenic mice?
p-value: p=<0.05
The study demonstrates that MMP-2 and MMP-9 gene promoters are activated in distinct spatial and temporal patterns following myocardial infarction, providing insight into the cellular mechanisms of post-MI left ventricular remodeling.
Mukherjee et al. (2006) studied Myocardial infarction. Myocardial infarction induction was evaluated on Spatiotemporal patterns of gene promoter induction for MMP-2 and MMP-9 (beta-galactosidase reporter level) (p=<0.05). After induced myocardial infarction in transgenic mice, MMP-2 and MMP-9 promoter induction peaked at 7 days (64 +/- 6% and 53 +/- 6% of LV epicardial area, respectively; P<0.05).
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