Key result
Iron-particle irradiation (0.1 or 0.2 Gy) increased the average fractional volume of degenerated area in mouse coronary arteries to 28% and 24%, respectively, vs 12% in controls (P<0.01).
Why the study?
Does orbital irradiation with iron particles cause degenerative changes in the coronary arteries in B6CF1 female mice?
Does orbital irradiation with iron particles cause degenerative changes in the coronary arteries in B6CF1 female mice?
Answers are grounded in this paper and cite their sources.
Orbital irradiation with iron particles induces significant late structural degenerative changes in the coronary arteries of mice.
A single dose of 0.1 or 0.2 Gy iron particles was given to B6CF1 female mice at 4 months of age. Degenerative changes in the coronary arteries due to orbital irradiation were observed 15 months after irradiation. The major changes included smooth muscle degeneration with fibrosis and accumulation of debris and extracellular matrix in the medial layer of the vessels. Quantitative analysis indicates that the average fractional volume of degenerated area is 12% in the unirradiated group. The corresponding percentages are 28% (P < 0.01) and 24% (P < 0.01) after 0.1 and 0.2 Gy irradiation, respectively.
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Vivian C. Yang (1993) studied Coronary artery degeneration. Iron-particle irradiation vs. Unirradiated group was evaluated on Average fractional volume of degenerated area (p=<0.01). Iron-particle irradiation (0.1 or 0.2 Gy) increased the average fractional volume of degenerated area in mouse coronary arteries to 28% and 24%, respectively, vs 12% in controls (P<0.01).
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