Key result
LV GLS shows a U-shaped association with 24-month MACE in sepsis survivors.
Why the study?
Septic cardiomyopathy frequently develops in sepsis and likely increases short-term mortality, but whether it is associated with long-term outcomes after sepsis is unknown.
Does left ventricular global longitudinal systolic strain predict long-term major adverse cardiovascular events in adult ICU survivors of sepsis?
Cohort (n=290)
No
Does left ventricular global longitudinal systolic strain predict long-term major adverse cardiovascular events in adult ICU survivors of sepsis?
Hazard Ratio: 1.03
p-value: p=0.08
A U-shaped association between LV GLS and long-term MACE in sepsis survivors suggests that both unusually high and low contractility during sepsis mark increased long-term cardiovascular risk.
May flag sepsis survivors for extended CV surveillance; leaves open whether strain monitoring improves long-term outcomes.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Beesley et al. (2021) conducted a cohort in Sepsis (n=290). Left ventricular global longitudinal systolic strain (LV GLS) was evaluated on Major adverse cardiovascular events (death, stroke, and myocardial infarction) through 24 months after ICU discharge (HR 1.03 per 1-point increase, 95% CI <1.00-1.07, p=0.08). Left ventricular global longitudinal systolic strain demonstrated a highly significant U-shaped association with cardiovascular outcomes through 24 months in adult sepsis survivors (p < 0.001 for non-linear analysis).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: