Dysfunction of the physical and chemical barriers of the skin may play roles in the pathogenesis of atopic dermatitis (AD) by facilitating penetration of antigens through the skin and evoking aberrant immune reactions. This chapter reviews the roles of keratinocyte-derived cytokines and chemokines in the pathogenesis of AD in humans and dogs. To understand the current concept on the role of keratinocyte-derived cytokines and chemokines in the immunopathogenesis of AD, it summarizes studies describing human AD followed by the findings in canine atopic dermatitis (cAD). Antimicrobial peptides derived from keratinocytes play important roles in the chemical barrier function against various types of microorganisms. Thymus and activation-regulated chemokine (TARC/CCL17) is one of the most extensively investigated chemokines associated with cAD. Accumulated evidence demonstrates that keratinocyte-derived cytokines and chemokines, such as TARC/CCL17, granulocyte-macrophage colony-stimulating factor (GM-CSF), thymic stromal lymphopoietin (TSLP) and Interleukin-33 (IL-33), are involved in the pathogenesis of human AD and possibly in cAD.
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Asahina et al. (2017) studied this question.