Population
Frog's heart
Comparison
Alteration of external sodium concentration and… vs Normal external and intracellular sodium…
Design
Preclinical
Authors
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Challenges sodium hypothesis in amphibian hearts without clinical implications; leaves open calcium contributions to excitability for mammalian studies.
The study demonstrates that the action potential of the frog heart does not strictly follow the sodium hypothesis of excitation, suggesting calcium also plays a role in the excitable membrane.
Niedergerke et al. (1966) studied this question.
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