Key result
Central aortic blood pressure is associated with cardiovascular mortality and atherosclerosis, and is differentially impacted by antihypertensive therapies compared to peripheral blood pressure.
Why the study?
Does central aortic blood pressure provide important prognostic information for cardiovascular outcomes and respond differently to antihypertensive therapy compared to peripheral blood pressure?
Does central aortic blood pressure provide important prognostic information for cardiovascular outcomes and respond differently to antihypertensive therapy compared to peripheral blood pressure?
Central aortic blood pressure may serve as a more important marker of cardiovascular disease than peripheral blood pressure, with different classes of antihypertensive drugs affecting it differently.
Central aortic pressure may enhance CV risk assessment beyond peripheral measures; leaves open whether targeting it improves outcomes.
Elevated peripheral (brachial) blood pressure (PBP) is related to hard cardiovascular outcomes and remains the main target for antihypertensive therapy. However, central aortic blood pressure (CABP) can be measured noninvasively and could potentially prove to be a more important marker of cardiovascular diseases in future. Several studies have shown association of CABP with cardiovascular mortality, coronary artery disease, left-ventricular hypertrophy and atherosclerosis. Furthermore, the impact of various classes of antihypertensive agents on CABP is different from their impact on PBP. We review the significance of CABP in cardiovascular outcomes and the differential impact of antihypertensive therapy on CABP.
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Patel et al. (2011) conducted a review in Cardiovascular diseases. Central aortic blood pressure was evaluated. Central aortic blood pressure is associated with cardiovascular mortality and atherosclerosis, and is differentially impacted by antihypertensive therapies compared to peripheral blood pressure.
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