Key result
In normotensive patients, 24-h pulse pressure was the best independent predictor of coronary lesion severity (P=0.009), carotid IMT (P=0.003), and LV mass index (P=0.009).
Why the study?
Is 24-h arterial pulse pressure associated with the severity of coronary artery disease, carotid IMT, and LV mass index in normotensive patients with known coronary artery disease?
Cross-Sectional (n=110)
Is 24-h arterial pulse pressure associated with the severity of coronary artery disease, carotid IMT, and LV mass index in normotensive patients with known coronary artery disease?
p-value: p=0.009
In normotensive patients with coronary artery disease, 24-h pulse pressure is an independent marker of global cardiovascular risk, correlating with coronary severity, carotid IMT, and LV mass index.
The purpose of the present study was to evaluate the relation of the systemic arterial pulse pressure and other parameters derived from the 24-h arterial blood pressure (BP) monitoring to the severity of coronary artery disease, carotid lesions, and left ventricular (LV) mass index in patients without arterial hypertension. One hundred ten patients with known coronary artery disease underwent coronary arteriography, 24-h arterial BP monitoring, and ultrasound imaging of the carotid arteries and the myocardium. Measurements of 24-h arterial BP monitoring (systolic, diastolic, and average BP, pulse pressure, abnormal values of systolic and diastolic BP, and heart rate), the severity of coronary heart disease (Gensini score), intima-media thickness (IMT) of the common carotid artery and LV mass index were determined in all patients. By univariate analysis, only 24-h pulse pressure was significantly related to the severity of coronary artery disease (P < .01), carotid IMT(P < .01), and LV mass index (P < .01). In a multivariate analysis, 24-h pulse pressure was also the best predictor of the severity of coronary lesions (P = .009), carotid IMT (P = .003), and LV mass index (P = .009). Gensini score was related (P < .01) to LV mass index and not to carotid IMT. In conclusion, systemic arterial pulse pressure derived from 24-h arterial BP monitoring is related to coronary artery disease, carotid IMT, and LV mass index independently of age or any other derivative of 24-h arterial BP monitoring, indicating that this parameter could be a marker of global cardiovascular risk.
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Nikos Zakopoulos (2001) conducted a cross-sectional in Coronary artery disease without arterial hypertension (n=110). 24-h pulse pressure vs. Other 24-h BP parameters was evaluated on Severity of coronary artery disease (Gensini score), carotid IMT, and LV mass index (p=0.009). In normotensive patients, 24-h pulse pressure was the best independent predictor of coronary lesion severity (P=0.009), carotid IMT (P=0.003), and LV mass index (P=0.009).
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