Key result
High-intensity exercise reduces platelet reactivity and clot density in early but not late postmenopausal women.
Why the study?
Does high-intensity exercise training improve thrombogenic profiles in recent versus late postmenopausal females?
Does high-intensity exercise training improve thrombogenic profiles in recent versus late postmenopausal females?
High-intensity exercise training initiated soon after menopause, but not late after menopause, improves thrombogenic profiles, suggesting early intervention is more effective for reducing blood clot risk.
High-intensity exercise may improve thrombogenic profiles only early postmenopause; hypothesis-generating and requires randomized confirmation before practice change.
Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot density and strength in females ≤5 yr past menopause but not in females ≥10 yr past menopause. The divergent response in the late postmenopausal females may be explained by training-induced low-grade systemic inflammation. These findings suggest that regular physical activity initiated soon after menopause, compared with many years after menopause, may be more efficient for reducing the risk of blood clots.
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Nørregaard et al. (2023) studied Postmenopause. High-intensity exercise training vs. Late postmenopausal females (≥10 years past menopause) was evaluated on Platelet reactivity, blood clot density and strength. Eight weeks of high-intensity exercise training reduced platelet reactivity and blood clot density in females ≤5 years past menopause, but not in those ≥10 years past menopause.
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