Insulin-Like Growth Factor-I Resistance*

I. Introduction II. The IGFs and Their Receptors III. Genetically Engineered Mouse Models IV. Malnutrition V. Conditions Associated with Genetic IGF-I Resistance in Humans A. African Efe Pygmies B. Leprechaunism and other genetic disorders associated with severe insulin resistance C. Deletions of the distal arm of chromosome 15 D. Rare examples of “idiopathic” short stature associated with elevated circulating levels of IGF-I VI. Conditions Associated with Acquired IGF-I Resistance in Humans A. HIV-1 infection B. Chronic renal insufficiency C. Mauriac syndrome VII. Conclusions