PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 2, 1995European Heart Journal

Myocardial fibrosis in hypertensive heart disease: an overview of potential regulatory machanisms

View Full Paper
Ask AI
Bookmark
Share

Population

Patients with hypertensive heart disease (HHD)

Design

Review

Key result

Mechanisms of perivascular and interstitial fibrosis in hypertensive heart disease include angiotensin II-mediated vascular hyperpermeability, hormonal regulation, and autocrine/paracrine signaling.

Authors

KWK. T. WeberYSYao SunEGEduardo Guarda

Discussion

Loading...

Member takes

Overview

No immediate clinical implications; leaves open targeted antifibrotic trials in hypertensive heart disease.

Key Points

  • This overview examines the regulatory mechanisms involved in myocardial fibrosis in hypertensive heart disease.
  • Reviewed mechanisms of fibrosis related to hypertrophic left ventricle and normative right ventricle in hypertension.
  • Discussed roles of angiotensin II, aldosterone, and endothelins in fibrosis regulation.
  • Explored autocrine and paracrine signaling involved in collagen dynamics.
  • Identified angiotensin II as a key mediator of coronary vascular hyperpermeability and fibrosis.
  • Highlighted hormonal regulation of fibroblast collagen turnover by angiotensin II and other factors.
  • Discussed the dynamic nature of collagen turnover in cardiac fibrous tissue.

Structured PICO

P
Population
Patients with hypertensive heart disease (HHD)

This review outlines the regulatory mechanisms of perivascular and interstitial myocardial fibrosis in hypertensive heart disease, emphasizing the dynamic nature of collagen turnover and the roles of neurohormonal factors.

Limitations

  • Mechanisms responsible for scarring (reparative fibrosis) are not covered in this review.

Cite This Study

Weber et al. (1995) conducted a review in Hypertensive heart disease. Mechanisms of perivascular and interstitial fibrosis in hypertensive heart disease include angiotensin II-mediated vascular hyperpermeability, hormonal regulation, and autocrine/paracrine signaling.

synapsesocial.com/papers/6a23b1f1ffed3004559ee84fhttps://doi.org/10.1093/eurheartj/16.suppl_c.24
View Full Paper
Ask AI
Bookmark
Share